Phosphodiesterase 4A1A (PDE4A1A) 400 Assay Kit

The cyclic nucleotide phosphodiesterases (PDE) comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules. PDE4 isoforms are specifically implicated in airway inflammation, arthritis, learning, stroke, PD, and leukemia.